Notes- What interactions do you see between ibuprofen and aspirin? There can be a higher chance of developing gastrointestinal ulcers and bleeding, and it can decrease the effectiveness of aspirin in stopping heart attacks. You can also develop severe abdominal pain or bloating, or nausea and vomiting.
- What classification of interaction are they - major, moderate, or minor? The interaction between both is classified as a Major interaction.
- What is the definition of a major interaction? A major interaction means it is “clinically significant” - combining both drugs should be avoided; the risks outweigh the marginal benefit.